Contact lenses can predispose wearers to Corneal Ulcers, which can be sight-threatening. The annual risk of corneal ulcers from extended-wear contact lenses is 1 in 1,000, which equals 1 in 20 over 50 years. Any wearer with eye pain should remove the lens immediately. If the pain hasn’t gone away in 1-2 hours, they should seek care immediately, even if it means going to an E.R. The pain may just be from a simple Corneal Abrasion, which can be diagnosed in urgent care and most primary care settings, but it could be much worse.