Causes of Acute Upper Abdominal Pain
Right Upper Quadrant (RUQ) Hepatitis (Acute) Gallbladder Disease Pneumonia Stomach Ulcer [?] Muscle Strain Herpes Zoster (Shingles) [?] = sometimes in this area (but usually another) | xxxxxxxEpigastric Stomach Diseases: โข Ulcer / Gastritis / Dyspepsia xxxEsophageal Reflux (GERD) โข Gastric Cancer Pancreatitis Heart Attack Hepatitis [?] Gallbladder Disease [?] Muscle Strain Early Appendicitis NOT โGastroenteritisโ [?] = sometimes in this area (but usually another) | Left Upper Quadrant (LUQ) Pancreatitis Stomach Ulcer / Gastritis [?] Dyspepsia [?] Heart Attack [?] Muscle Strain Herpes Zoster (Shingles) [?] = sometimes in this area (but usually another) |
See also Diagrams — Gastrointestinal System

How Clinicians Approach Upper Abdominal Pain
1a. Decide if the patient may be having a Heart Attack (if so, call 911):
- โHeavyโ pain or pressure (Epigastric or LUQ) with short of breath, nausea, cold sweats on forehead, lightheaded. Worse with exertion.
- Risk Factors: Male >35 or female after menopause; smoker; high blood pressure; diabetes; high cholesterol; family history of parent or sibling with heart attack (at around same age); cocaine or amphetamine in past 1-2 days
- See also Diagnosing Coronary Artery Disease
IF NOTโฆ
1b. Decide if patientโs symptoms are bad enough to maybe need surgery, hospitalization, or same-day tests (if so, may send to E.R.):
- Doubled-over, clutching belly
- Very tender & board-like abdomen during exam
- Abdominal pain + Fever
- Patient who is immunocompromised
- Vomiting enough to become dehydrated
- Vomiting blood (at least a handful, not just specks), or vomiting coffee-ground material (could be blood)
- Stools look pitch-black [= clotted blood] (not just “dark”) (stools also turn black from iron pills, or medications like Pepto-Bismolยฎ)
IF NOTโฆ
2. Consider Non-Stomach Diseases (we order tests / diagnose if disease likely):
** Hepatitis (Acute) —
- Loss of appetite, nausea. Pain isn’t severe
- Jaundice (eyes / skin turn yellow)
- Right lower ribs tender when gently punched
- Diagnosis: blood test for Liver function Tests (ALT & AST)
- If positive, need additional tests to determine type of hepatitis and severity
- IF LIKELY, we order same-day tests, but don’t send to ER.
** Gallbladder Disease — Gallstones, etc.
- Abrupt onset pain, may radiate to right shoulder or right back
- Nausea, usually vomiting
- Tender to palpation under Right rib cage while breathing in
- History of prior episodes lasting up to 6 hrs. is convincing
- Diagnose by Ultrasound
- We SEND TO ER if fever, jaundice (yellow eyes), or pain lasting >6 hrs.
** Pneumonia (right lung) —
- Maybe just sudden, severe pain in the RUQ area, hurts worse with breathing
- Cough & fever eventually occur soon (usually the same day)
- Diagnose by chest x-ray, NEEDS IT SAME DAY
** Pancreatitis —
- Moderate-to-severe pain in the Epigastric or LUQ areas, tender to palpation
- Nausea / Vomiting very common
- Suspect in alcoholics, & patients with very high blood triglycerides (>500-1,000)
- Diagnose by high Lipase in blood; CT Scan to confirm diagnosis & rule-out complications
- NEED BLOOD TESTS THAT SAME DAY
** Muscle Strain — Very common cause of abdominal pain
- Pain increased with motions of torso
- Most tenderness to palpation occurs while patient flexes abs (like doing a partial sit-up); less or no tenderness while lies relaxed
- No nausea / vomiting / fever
- No suggestion of anything more serious
** Herpes Zoster (Shingles) —
- Red splotchy rash, usually with same blisters, in a stripe-like area from spine to mid abdomen, on one side
- Impossible to diagnose before the rash appears
3. IF NONE OF THE ABOVE diseases seems likely, diagnose a condition of the STOMACH
Try to distinguish between Ulcer or Gastritis on the one hand, versus Dyspepsia or Gastro-Esophageal Reflux Disease (GERD) on the other:
- Ulcer & Gastritis occur daily, last the better part of the day, are more bothersome
- Dyspepsia often doesn’t occur daily, comes & goes, lasts less time each day
- GERD provokes burning or discomfort going up into the chest, is otherwise similar to Dyspepsia
a) If suspect Ulcer or Gastritis:
- Order a test for H. pylori bacteria โ Treat if positive.
- If no H. pylori โ Treat with a Proton Pump Inhibitor (PPI) for 2 months
- If age >45-50 yrs-old, give PPI for 3 weeks. If gets better, change to another antacid medicine
- If pain recurs, send to Gastroenterologist for endoscopy (to rule out Stomach Cancer)
b) If suspect Dyspepsia / GERD
- Treat with a Proton Pump Inhibitor (PPI) for a few wks. If gets better, change to another antacid medicine
- If age >45-50 yrs-old and pain recurs, send to Gastroenterologist for endoscopy (to rule out Stomach Cancer)
- If age <45, test for H. pylori (treat if positive) before sending to Gastroenterologist.
4. Don’t forget Early Appendicitis during the first 1-2 days of upper abdominal pain.
- If patient not very ill, we instruct that if pain gets worse, moves to the Right Lower Quadrant, and nausea starts, GO TO E.R.
See Upper Abdominal Pain โ Full Text for more in-depth explanations and discussions.